IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas
نویسندگان
چکیده
منابع مشابه
Marginal zone lymphomas: management of nodal, splenic, and MALT NHL.
Marginal zone lymphomas are indolent B-cell lymphomas that originate from the marginal zone of B-cell follicles. For several subtypes, the initiation of disease appears to be a consequence of chronic infection and/ or inflammation. While the initial lymphoid hyperplasia is driven by physiologic antigenic stimulation, additional oncogenic events, such as chromosomal translocations leading to con...
متن کاملNodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes.
Nodal marginal zone B-cell lymphoma (MZL) is a rare and not extensively studied entity that accounts for approximately 2% of all non-Hodgkin lymphomas. Complementarity-determining regions 2 and 3 (CDR2, CDR3) of the immunoglobulin heavy-chain variable region (V(H)) genes were amplified by polymerase chain reaction (PCR), cloned, and sequenced in 8 patients with nodal MZL. All showed a potential...
متن کاملNon-MALT marginal zone lymphomas.
The concept of marginal zone B-cell lymphomas was developed in the 1990s for lymphomas whose cells originate from B lymphocytes normally present in a distinct anatomical location, the so-called ‘marginal zone’ (MZ). MZ has been described in the lymphoid organs—spleen and lymph nodes—and in nonlymphoid organs—mucosa-associated lymphoid tissue (MALT) or non-mucosal tissue such as skin, orbit and ...
متن کاملCARMA1 and chromosomal translocations in extranodal marginal zone B-cell lymphomas of MALT type or diffuse large B-cell lymphomas.
We analyzed the configuration of the CARMA1 gene, encoding a protein that closely interacts with BCL10 and MALT1, in a series of 120 extranodal marginal zone B-cell lymphomas of MALT-type and 35 diffuse large B-cell lymphomas. Our study suggests that CARMA1 is not targeted by chromosomal translocations in these lymphoma entities.
متن کاملChronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas.
Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymph...
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ژورنال
عنوان ژورنال: Histopathology
سال: 2012
ISSN: 0309-0167
DOI: 10.1111/j.1365-2559.2012.04289.x